In CF, what is the consequence of pancreatic duct blockage?

In CF, what is the consequence of pancreatic duct blockage?

• A. Pancreatic enzymes cannot reach the duodenum to aid digestion
• B. Overproduction of pancreatic enzymes
• C. Pancreas stops producing enzymes
• D. Digestion is normal

Answer: (D)

In cystic fibrosis, thick secretions block the pancreatic ducts, so the exocrine pancreas cannot deliver its enzymes into the small intestine. Because these enzymes—especially lipase—are not reaching the duodenum, digestion of fats (and other nutrients) is impaired, leading to malabsorption and often steatorrhea. The pancreas may still produce enzymes, but their delivery is blocked, so digestion isn’t normal. This is why the statement that digestion remains normal isn’t accurate, and the description that pancreatic enzymes can’t reach the duodenum to aid digestion best fits the situation. Pancreatic enzyme replacement is a key part of management to address this deficiency.

In cystic fibrosis, thick secretions block the pancreatic ducts, so the exocrine pancreas cannot deliver its enzymes into the small intestine. Because these enzymes—especially lipase—are not reaching the duodenum, digestion of fats (and other nutrients) is impaired, leading to malabsorption and often steatorrhea. The pancreas may still produce enzymes, but their delivery is blocked, so digestion isn’t normal. This is why the statement that digestion remains normal isn’t accurate, and the description that pancreatic enzymes can’t reach the duodenum to aid digestion best fits the situation. Pancreatic enzyme replacement is a key part of management to address this deficiency.